Sason Shaik
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel
Corresponding Author: sason.shaik@gmail.com
Abstract:
This talk outlines my outlook on the development of electric-field-mediated chemistry/biochemistry, and predicts a vision of its future state. It discusses applications of oriented electric fields (OEFs) to chemical and biochemical reactions, such as Diels-Alder reactions and reactions of the enzyme Cytochrome P450. As we will demonstrate, the orientation of the OEF controls reaction-rate acceleration/inhibition, chemo-selectivity, enantio-selectivity, and solvent effect. The talk will include relevant experimental verifications of the impact of OEF on structure and reactivity. We will also explore other methods of generating EFs, such as pH-switchable charges, ionic additives, and water droplets. Additionally, the application of static versus oscillating OEFs for decomposing peptide plaques, such as those associated with Alzheimer’s disease, will be discussed.
The second part of the talk summarizes conceptual principles for understanding and predicting OEF effects, including the “reaction-axis rule” and the capability of oriented external electric fields to act as tweezers that orient reactants and accelerate reactions. Finally, the talk will address the potential for up-scaling various OEF sources, potentially achieving Molar concentrations. I conclude with the vision that OEF usage could transform chemical education and the art of molecule creation in the coming years.
Keywords:
Oriented Electric Field, External Field, Molecular Fields, Reaction Axis, Reaction Control
Suggested Reading:
- Shaik, S. "My Vision of the Future of Electric-Field-Aided Chemistry in 2050". ACS Phys. Chem. Au, 2024, 4, 191-201. https://doi.org/10.1021/acsphyschemau.3c00064
- Shaik, S.; Ramanan, R.; Danovich, D.; Mandal, D. Chem. Soc. Rev. (Tutorial), 2018, 47, 5125-5145.
- Kalita, S.; Bergman, H.; Dubey, K.D.; Shaik, S. J. Am. Chem. Soc. 2023, 145, 3543-3553.
Virtual Winter School on Computational Chemistry